Ndfip1, a new PTEN regulator in neurons - 1/ 2012

Loss of blood supply to the brain results in infarcts. To prevent irreversible cell death neurons sharply increase the levels of Ndfip1 protein. This promotes Pten nuclear transport, in concert with the Nedd4 ubiquitin ligase. As a consequence, a transient increase in cytoplasmic Akt can support neuronal survival until blood supply is restored. These findings uncover the first physiological relevance of Pten trafficking in cells.

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PTEN and PHLPP1 status in prostatectomy - 10/ 2011

Measuring combined RNA expression levels of the two tumor suppressor genes PHLPP1 and PTEN could allow for prediction of disease outcome in surgical samples.

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The PHLPP genes block prostate cancer - 8/ 2011

Our search for the mechanisms behind prostate cancer and its progression to lethal disease has led to identification of the PHLPP genes as critical tumor suppressors. PHLPP1 is frequently degraded at the protein level and its RNA expression is often suppressed in cancers. The DNA copy number alteration patterns allow us to establish a principle for disease progression.

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Yeast is safe - 11/2009

The long-standing tradition of Harbor Brews has returned to the James building (est’d. 1929). Our premium beers include the legendary James Blond, award winning beverage of the 2009 Movember Parté.

Stay tuned for the launch of our Spring creation.

Seeing the lethal in prostate cancer - 8/ 2009

While human genomic analysis affords us snapshots of tumorigenesis we can learn about the sequence and consequences of genetic alterations from genetically engineered mouse models of the disease. With this project we aim to understand the stepwise progression from benign to lethal cancer and define a signature that is characteristic for the process.